Mending a broken heart but breaking the kidney
نویسندگان
چکیده
منابع مشابه
Mending a broken heart: the role of mitophagy in cardioprotection.
The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage. Therefore, maintaining a functional population of mitochondria is critical for cardiac function. Efficient degradation and replacement of dysfunctional mitoch...
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Ventricular remodeling following myocardial infarction (MI) is a complex process driven by the response of both the myocytic and the nonmyocytic components of the heart to dynamic mechanical and neurohumoral stimuli. Despite the advent of reperfusion therapy and the administration of drugs slowing the progression of heart failure, many patients experiencing a MI undergo a progressive decline in...
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Cardiovascular disease (CVD), which includes hypertension, coronary heart disease (CHD), stroke, and congestive heart failure (CHF), has ranked as the number one cause of death in the United States every year since 1900 except 1918, when the nation struggled with an influenza epidemic. In 2002, CVD claimed roughly as many lives as cancer, chronic lower respiratory diseases, accidents, diabetes ...
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D uchenne muscular dystrophy (DMD) is the most severe and most common form of X-linked muscular diseases. It has been known for over 25 years that DMD is caused by a gene mutation leading to the near total absence of functional dystrophin protein. Transcription of the gene is controlled by 3 independent promoters of which the muscle (M) promoter drives high expression of dystrophin in skeletal ...
متن کاملMending a Faltering Heart.
More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of ...
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ژورنال
عنوان ژورنال: Nephrology
سال: 2016
ISSN: 1320-5358
DOI: 10.1111/nep.12799